Article
A genetic model of congenital intestinal atresia implicates Mypt1 in epithelial organisation.
Disease models & mechanisms - 1 Feb 2026
Kobayashi Daisuke, Urasaki Akihiro, Kimura Tetsuaki, Ansai Satoshi, Matsuo Kazuhiko, Yokoi Hayato, Takashima Shigeo, Kitagawa Tadao, Kage Takahiro, Narita Takanori, Jindo Tomoko, Kinoshita Masato, Naruse Kiyoshi, Nakajima Yoshiro, Shigeta Masaki, Sakaki Shinichiro, Inoue Satoshi, Saba Rie, Yamada Kei, Yokoyama Takahiko, Ishikawa Yuji, Araki Kazuo, Saga Yumiko, Takeda Hiroyuki, Yashiro Kenta
Abstract excerpt
Congenital intestinal atresia (IA) is a birth defect characterised by the absence or closure of part of the intestine. Although genetic factors are implicated, mechanistic understanding has been hindered by the lack of suitable animal models. Here, we describe a medaka (Oryzias latipes) mutant, generated by N-ethyl-N-nitrosourea (ENU) mutagenesis, that develops IA during embryogenesis. Positional cloning...
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