Article

Arylsulfamates inhibit colonic <i>Bacteroides</i> growth through lipid kinases and not sulfatases

2024-04-28

Abstract excerpt

Excessive degradation of the colonic mucin layer by Bacteroides within the human gut microbiota drives inflammatory bowel disease in mice. Bacterial carbohydrate sulfatases are key enzymes in gut colonization, as they are elevated in human inflammatory bowel disease and correlate with disease severity. Selective inhibitors of carbohydrate sulfatases could function as sulfatase-selective drugs, allowing precise co...

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Literature Corpus work: b42df2a3-6608-5c08-919f-d31c30d936aa
DOI: 10.1101/2024.04.27.591440

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