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UGT2B7 372A>G Polymorphism Is Related To a Therapeutic Response to Lamotrigine Augmentation Therapy in Depressed Patients Who Did Not Respond to Adequate Treatment: A Preliminary Study

2022-01-17

Abstract excerpt

<title>Abstract</title> <p><bold>Purpose:</bold> Lamotrigine is mainly metabolized by UGT1A4 and UGT2B7, both of which are expressed in the blood–brain barrier. Polymorphisms of said <italic>UGTs</italic> that affect enzyme activities have been reported. This study investigated the relationship between these polymorphisms and its therapeutic effect in 55 depressed patients who did not respond to adequate treatmen...

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Literature Corpus work
b41a2a18-ddd1-58c3-a3d8-56e85f696493
DOI
10.21203/rs.3.rs-1262527/v1
Open publication

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UGT2B7 372A&gt;G Polymorphism Is Related To a Therapeutic Response to Lamotrigine Augmentation Therapy in Depressed Patients Who Did Not Respond to Adequate Treatment: A Preliminary StudyDOI 10.21203/rs.3.rs-1262527/v1
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