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Impact of UGT1A4 and UGT2B7 polymorphisms on lamotrigine plasma concentration in patients with bipolar disorder.

Pharmacogenetics and genomics - 1 Oct 2024

Zhao Ting, Zhang Hui-Lan, Feng Jie, Cui Long, Sun Li, Li Hong-Jian, Yu Lu-Hai

Abstract excerpt

PURPOSE: The purpose of this study was to evaluate the effect of UGT1A4 and UGT2B7 polymorphisms on the plasma concentration of lamotrigine in Chinese patients with bipolar disorder. METHODS: A total of 104 patients were included in this study. Steady-state plasma lamotrigine concentrations were determined in each patient after at least 21 days of continuous treatment with a set dose of the drug. Lamotrigine...

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PMID: 39171428
DOI: 10.1097/FPC.0000000000000543

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