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Article

Frequencies of UGT1A42 (P24T) and 3 (L48V) and their effects on serum concentrations of lamotrigine.

European journal of drug metabolism and pharmacokinetics - 1 Apr 2016

Reimers Arne, Sjursen Wenche, Helde Grethe, Brodtkorb Eylert

Abstract excerpt

The gene encoding uridine diphosphate glucuronosyltransferase (UGT) 1A4 shows considerable polymorphism. Several common drugs are metabolised by UGT1A4, among them lamotrigine (LTG). Experimental and clinical studies suggest that certain variants of UGT1A4 are associated with altered enzyme activity. However, results are conflicting. This clinical study aimed to investigate the frequencies of two common UGT1A4...

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Identifiers

PMID: 25492569
DOI: 10.1007/s13318-014-0247-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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