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Article

Second-site homologous recombination in Epstein-Barr virus: insertion of type 1 EBNA 3 genes in place of type 2 has no effect on in vitro infection.

Journal of virology - 1 Feb 1992

Tomkinson B, Kieff E

Abstract excerpt

This study was undertaken to develop a general strategy for the introduction of mutations into specific sites in the Epstein-Barr virus (EBV) genome. Previous approaches were limited by the need for physical linkage of the transfected EBV DNA fragment to a positive selection marker. In our experiments, a positive selection marker was introduced into one site in the EBV genome and a distant, nonlinked, marker was...

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Identifiers

PMID: 1309912
DOI: 10.1128/JVI.66.2.780-789.1992
PMCID: PMC240778

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