Second-site homologous recombination in Epstein-Barr virus: insertion of type 1 EBNA 3 genes in place of type 2 has no effect on in vitro infection.

doi:10.1128/JVI.66.2.780-789.1992

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Article

Second-site homologous recombination in Epstein-Barr virus: insertion of type 1 EBNA 3 genes in place of type 2 has no effect on in vitro infection.

Journal of virology - 1 Feb 1992

Tomkinson B, Kieff E

Abstract excerpt

This study was undertaken to develop a general strategy for the introduction of mutations into specific sites in the Epstein-Barr virus (EBV) genome. Previous approaches were limited by the need for physical linkage of the transfected EBV DNA fragment to a positive selection marker. In our experi...

Topics

Amino Acid Sequence
Antigens, Viral
B-Lymphocytes
Base Sequence
Cell Line
Cell Transformation, Viral
Cells, Cultured
Cosmids
DNA, Viral
Epstein-Barr Virus Nuclear Antigens
Genes, Viral
Genetic Markers
Genome, Viral
Genotype
Herpesvirus 4, Human
Humans
Immunophenotyping
Molecular Sequence Data

Source

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Identifiers

PMID: 1309912
DOI: 10.1128/JVI.66.2.780-789.1992
PMCID: PMC240778

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1309912-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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