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Article

Ethosuximide ameliorates neurodegenerative disease phenotypes by modulating DAF-16/FOXO target gene expression.

Molecular neurodegeneration - 29 Sept 2015

Chen Xi, McCue Hannah V, Wong Shi Quan, Kashyap Sudhanva S, Kraemer Brian C, Barclay Jeff W, Burgoyne Robert D, Morgan Alan

Abstract excerpt

BACKGROUND: Many neurodegenerative diseases are associated with protein misfolding/aggregation. Treatments mitigating the effects of such common pathological processes, rather than disease-specific symptoms, therefore have general therapeutic potential. RESULTS: Here we report that the anti-epileptic drug ethosuximide rescues the short lifespan and chemosensory defects exhibited by C. elegans null mutants of...

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Identifiers

PMID: 26419537
DOI: 10.1186/s13024-015-0046-3
PMCID: PMC4587861

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DNAJC5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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