Article

Heritability and Multipoint Linkage Analysis Suggest the Contribution of Angiopoietin-TEK Pathway to the Variation of Serum Creatinine and Glomerular Filtration Rate

2022-02-14

Abstract excerpt

<h4>Background: </h4> Serum creatinine and estimated glomerular filtration rate (eGFR) are keys to assess kidney function and suggest a propensity for development of renal failure. Genetic factors are reported in different ethnic groups to play a role in the variability of these phenotypes. In this study, we investigate the heritability and quantitative trait loci (QTL) of serum creatinine and eGFR. Multiple pheno...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b3e4451f-be56-578a-9b9c-61ee233f7551
DOI: 10.21203/rs.3.rs-1242689/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Heritability and Multipoint Linkage Analysis Suggest the Contribution of Angiopoietin-TEK Pathway to the Variation of Serum Creatinine and Glomerular Filtration RateDOI 10.21203/rs.3.rs-1242689/v1Read

Disentangling shared genetic etiologies for kidney function and cardiovascular diseasesSemantic proximity Read

Distinct and shared genetics of kidney filtration function versus albuminuria revealed by multi-trait GWASSemantic proximity Read

1000 Genomes-based meta-analysis identifies 10 novel loci for kidney function.Semantic proximity Read

Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations.Semantic proximity Read

Discovery of genomic and transcriptomic pleiotropy between kidney function and soluble receptor for advanced glycation end-products using correlated meta-analyses: The Long Life Family Study (LLFS)Semantic proximity Read

Discovering Novel Loci of Chronic Kidney Disease via Principal Component Analysis-Based Multiple-Trait Genome-Wide Association Study.Semantic proximity Read

Kidney omics in hypertension: from statistical associations to biological mechanisms and clinical applications.Semantic proximity Read

African ancestry meta-analysis of genome-wide association studies identifies a novel locus and validates multiple loci associated with kidney functionSemantic proximity Read

Genome-Wide Association Study of Creatinine Clearance Identifies New Loci for Kidney FunctionSemantic proximity Read

Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function.Semantic proximity Read

Sex-specific and pleiotropic effects underlying kidney function identified from GWAS meta-analysisSemantic proximity Read

Meta-analysis of African ancestry genome-wide association studies identified novel locus and validates multiple loci associated with kidney function.Semantic proximity Read