Article

Mechanistic insights into Down syndrome comorbidities via convergent RNA-seq and TWAS signals

2025-06-08

Abstract excerpt

Down syndrome (DS) is caused by trisomy of chromosome 21 and is associated with diverse clinical manifestations, yet the molecular pathways linking chromosome-21 dosage effects to DS comorbidities remain poorly defined. Here we address this gap by applying a network-based, integrative framework that combines whole-blood transcriptomic data with gene-trait associations to uncover mechanistic insights into DS-associ...

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Literature Corpus work: 07e67b26-e3b3-5d4f-b4d2-fc417fd8e367
DOI: 10.1101/2025.06.05.658129

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