Article

The Allosteric Tug-of-War: Competitive Zinc and Dopamine Binding at the N-Terminal G14R Mutation Site of α-Synuclein

2026-01-07

Abstract excerpt

<title>Abstract</title> <p>The G14R mutation in α-synuclein is associated with aggressive, early-onset Parkinson’s disease, yet its impact on the protein’s N-terminal regulatory domain remains poorly understood. As an intrinsically disordered protein, α-synuclein’s conformational landscape is highly sensitive to sequence perturbations and ligand interactions. This study investigates a hypothesized "allosteric tug...

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Literature Corpus work: 9fd9c657-05a3-58ab-8af5-bb56448e8146
DOI: 10.21203/rs.3.rs-8515260/v1

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