Back to search

Article

Real-world effects of ACE inhibitors and Angiotensin Receptor Blockers: protocol for an emulation study of the ONTARGET trial using electronic health records

2021-03-24

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Introduction</h4> Cardiovascular disease (CVD) is a leading cause of death globally, responsible for nearly 18 million deaths worldwide in 2017. Medications to reduce the risk of cardiovascular events are prescribed based upon evidence from clinical trials which explore treatment effects in an indicated sample of the general population. However, these results may not be fully generalisable be...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
b3cd643c-c394-5441-b2ec-589bef3654d1
DOI
10.1101/2021.03.15.21251990
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Real-world effects of ACE inhibitors and Angiotensin Receptor Blockers: protocol for an emulation study of the ONTARGET trial using electronic health recordsDOI 10.1101/2021.03.15.21251990
Cardiorenal Effects of Angiotensin-converting enzyme inhibitors and Angiotensin receptor blockers in people underrepresented in trials: analysis of routinely collected data with validation against a target trialSemantic proximity
Enhancing evidence-based guidelines using trial emulation in electronic health records: Real-world effects of empagliflozin in people with type 2 diabetesSemantic proximity
Long-term Effectiveness of PCSK9 Inhibitors versus Ezetimibe as Adjunctive Therapy to Statins in Patients with Atherosclerotic Cardiovascular Disease: A TriNetX Database AnalysisSemantic proximity
Cardiorenal Outcomes with Finerenone in Patients Post-Acute Myocardial Infarction: Insights from a Global Federated NetworkSemantic proximity
Comparative Effectiveness of Second-line Antihyperglycemic Agents for Cardiovascular Outcomes: A Large-scale, Multinational, Federated Analysis of the LEGEND-T2DM StudySemantic proximity
Beyond Signal Detection: Sequential Target Trial Emulations to Confirm Previously Detected Adverse Drug Event Signals for Atorvastatin in Older Medicare BeneficiariesSemantic proximity
Optimising Prescription of Treatment In older patients with Mild hypertension at Increased risk of Serious adverse Events (OPTIMISE2): Protocol for a primary care based, open-label, randomised controlled non-inferiority trialSemantic proximity
Characteristics and Predictors of Apparent Treatment Resistant Hypertension in Real-World Populations Using Electronic Health Record-Based DataSemantic proximity
Replicating cardiovascular outcome trials of medications used to treat type 2 diabetes using real-world data: A systematic review of observational studiesSemantic proximity
Emulating randomized controlled trials of long-acting insulins and cardiovascular events using real-world data for patients with type 2 diabetesSemantic proximity
Renin-angiotensin system blockers and susceptibility to COVID-19: a multinational open science cohort studySemantic proximity
Linked electronic health records for research on a nationwide cohort including over 54 million people in EnglandSemantic proximity
Select a neighboring publication to make it the new centre.