Back to search

Article

Beyond Signal Detection: Sequential Target Trial Emulations to Confirm Previously Detected Adverse Drug Event Signals for Atorvastatin in Older Medicare Beneficiaries

2026-08-14

Abstract excerpt

Importance: Active pharmacovigilance via sequential target trial emulation can detect adverse drug event (ADE) signals missed by spontaneous reporting, yet signals identified through high-dimensional screening require rigorous, pre-specified confirmation that addresses residual confounding, outcome heterogeneity, multiplicity, and absolute risk. <h4>Objective: </h4> To confirm or refute previously detected ADE si...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
91c67e6d-3f09-5efd-984d-e65425fee362
DOI
10.64898/2026.08.12.26360302
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Beyond Signal Detection: Sequential Target Trial Emulations to Confirm Previously Detected Adverse Drug Event Signals for Atorvastatin in Older Medicare BeneficiariesDOI 10.64898/2026.08.12.26360302
Integrating Causal Inference into Pharmacovigilance: Target Trial Emulations for Proactive Signal Detection of Atorvastatin Initiation in Medicare BeneficiariesSemantic proximity
Emulation of placebo-controlled index trials using observational data with cloning, censoring and weighting: Empirical assessment of constraints and credibilitySemantic proximity
Low-Density Lipoprotein Cholesterol and Dementia Risk: Integrating Mendelian Randomization and Target Trial Emulation Within the Heart–Brain AxisSemantic proximity
Real-world effects of ACE inhibitors and Angiotensin Receptor Blockers: protocol for an emulation study of the ONTARGET trial using electronic health recordsSemantic proximity
The Adverse Event Atlas and Signal Consensus Index: A Multi-Source Pharmacovigilance PlatformSemantic proximity
Detecting adverse reaction signals to statins in a Chinese regional healthcare database, using a tree-based scan statistic methodSemantic proximity
Age-Stratified ICU Mortality Is Systematically Miscalibrated in Published Clinical Estimates: Cross-Validated Evidence from 201,905 Encounters Across Two Independent DatasetsSemantic proximity
Long-term Effectiveness of PCSK9 Inhibitors versus Ezetimibe as Adjunctive Therapy to Statins in Patients with Atherosclerotic Cardiovascular Disease: A TriNetX Database AnalysisSemantic proximity
Target trial emulation for a two-arm, parallel, stratified pragmatic RCT of CABG versus PCI in people with high-risk characteristics requiring myocardial revascularisation (High-Risk REVASC)Semantic proximity
High-Throughput Observational Evidence Generation Using Linked Electronic Health Record and Claims DataSemantic proximity
Cardiorenal Effects of Angiotensin-converting enzyme inhibitors and Angiotensin receptor blockers in people underrepresented in trials: analysis of routinely collected data with validation against a target trialSemantic proximity
A plasmode simulation-based bias analysis for residual confounding by unmeasured variables leveraging information-rich subsetsSemantic proximity
Select a neighboring publication to make it the new centre.