Article

mSigHdp: hierarchical Dirichlet process mixture modeling for mutational signature discovery

2022-02-02

Abstract excerpt

Mutational signatures are characteristic patterns of mutations caused by endogenous or exogenous mutational processes. These signatures can be discovered by analyzing mutations in large sets of samples – usually somatic mutations in tumor samples. Most programs for discovering mutational signatures are based on non-negative matrix factorization (NMF). Alternatively, signatures can be discovered using hierarchical...

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Literature Corpus work: 67c63448-1936-5a3a-bc37-c9d36addbc03
DOI: 10.1101/2022.01.31.478587

Open publication

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