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Causal Roles of Lipids and Mediating Proteins in Diabetic Retinopathy: Insights from Metabolomic and Proteomic Mendelian Randomization

2025-04-02

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold> This study explores the causal relationships between five major lipids, 249 circulating metabolites, and four diabetic retinopathy (DR) outcomes: overall DR, background DR, severe background DR, and proliferative DR (PDR). We aim to identify plasma proteins that mediate these causal effects, offering insights into potential therapeutic targets. <bold>Methods:</b...

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Literature Corpus work
b39f453d-2288-5843-abac-5e6411f3773f
DOI
10.21203/rs.3.rs-5904494/v1
Open publication

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