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Novel High-Resolution Lipidomes Could Serve as New Biomarkers for Diabetic Retinopathy: A Bidirectional and Mediated Mendelian Randomization Study.

Journal of cellular and molecular medicine - 1 Jun 2025

Sun Yuxin, Zhang Ziran, Chen Zejun, Li Zhengran, Wang Zijin, Wu Fanye, Ma Xinyu, Wang Shaoyu, Cao Mingzhe, Yi Guoguo, Fu Min

Abstract excerpt

Although lipid metabolism is a critical factor in the pathogenesis of diabetic retinopathy (DR), the connection between lipidome and DR is still a subject of debate. We aimed to demonstrate that lipidome could serve as novel biomarkers for DR and elucidate the mediating role of inflammatory factors. Data for our investigation are available from the GWAS catalogue and FinnGen Biobank. The bidirectional Mendelian...

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Biomarkers
Diabetic Retinopathy
Genome-Wide Association Study
Lipid Metabolism
Lipidomics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mendelian Randomization Analysis

Polymorphism, Single Nucleotide

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PMID: 40464192
DOI: 10.1111/jcmm.70614
PMCID: PMC12134777

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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