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Article

PTPN11-related Noonan syndrome predisposes to multifocal low-grade CNS tumors harboring FGFR1 variants.

Journal of neuro-oncology - 5 Mar 2026

Kohanbash Gary, Ryall Scott, Gary Sam E, Hoffman Lindsey M, Siddaway Robert, Bendel Anne E, Gripp Karen W, Walter Andrew W, Hansford Jordan R, Smith Amy A, Wang Hong, Skaugen John M, Tabori Uri, Hawkins Cynthia E, Broniscer Alberto

Abstract excerpt

PURPOSE: To characterize the clinical, radiological, and molecular characteristics of CNS tumors associated with Noonan syndrome (NS) and other non-Neurofibromatosis type 1 RASopathies. METHODS: Twenty-four patients with concern for NS underwent clinical and central radiological review in this multi-institutional study. Whole-exome sequencing, RNA sequencing, and methylation analyses of peripheral blood and/or...

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Source

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Identifiers

PMID: 41784910
DOI: 10.1007/s11060-026-05478-7
PMCID: PMC12963110

Genes

PTPN11
FGFR1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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PTPN11-related Noonan syndrome predisposes to multifocal low-grade CNS tumors harboring FGFR1 variants.PMID 41784910Read ↗

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