Article

Endogenous Retroviral Elements Generate Pathologic Neutrophils and Elastase Rich Exosomes in Pulmonary Arterial Hypertension

2021-01-09

Abstract excerpt

<h4>ABSTRACT</h4> Neutrophil elastase (NE) is implicated in pulmonary arterial hypertension (PAH) but the role of neutrophils in the pathogenesis of PAH is unclear. Here we show that neutrophils from PAH vs. control subjects produce and release increased NE associated with enhanced extracellular trap formation. PAH neutrophils are highly adherent and show decreased migration consistent with increased vinculin, id...

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Literature Corpus work: 4fc769b2-48b2-5547-a724-f50429dc4c51
DOI: 10.1101/2021.01.08.426001

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