Article

Rewriting nuclear epigenetic scripts in mitochondrial diseases as a strategy for heteroplasmy control

2024-12-31

Abstract excerpt

<h4>ABSTRACT</h4> Mitochondrial diseases, caused by mutations in either nuclear or mitochondrial DNA (mtDNA), currently have limited treatment options. For mtDNA mutations, reducing mutant-to-wild-type mtDNA ratio (heteroplasmy shift) is a promising therapeutic option, though current approaches face significant challenges. Previous research has shown that severe mitochondrial dysfunction triggers an adaptive nucl...

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Literature Corpus work: b351bb29-94df-5080-8f67-736b5d48281c
DOI: 10.1101/2024.12.30.630791

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