Article
Mitochondrial regulation of epigenetics and its role in human diseases.
Epigenetics - 1 Apr 2012
Minocherhomji Sheroy, Tollefsbol Trygve O, Singh Keshav K
Abstract excerpt
Most pathogenic mitochondrial DNA (mtDNA) mutations induce defects in mitochondrial oxidative phosphorylation (OXPHOS). However, phenotypic effects of these mutations show a large degree of variation depending on the tissue affected. These differences are difficult to reconcile with OXPHOS as the sole pathogenic factor suggesting that additional mechanisms contribute to lack of genotype and clinical phenotype...
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