Analysis of combinatorial chemokine receptor expression dynamics using multi-receptor reporter mice

Abstract excerpt

<h4>Summary</h4> Inflammatory chemokines and their receptors are central to the development of inflammatory/immune pathologies. The apparent complexity of this system, coupled with lack of appropriate in vivo models, has limited our understanding of how chemokines orchestrate inflammatory responses and has hampered attempts at targeting this system in inflammatory disease. Novel approaches are therefore needed to...

Topics

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• Chemokine receptors and signaling
• Computer Simulation
• Drug Design
• Immunotherapy and Immune Responses
• Ligands
• Mutation
• Receptors, Chemokine
• T-cell and B-cell Immunology

Identifiers and source

Literature Corpus work

b337ec61-3805-50ad-b4cc-4d81385eef21

DOI

10.1101/2021.08.11.455927