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Article

Identification of an optimized 2'-O-methylated trinucleotide RNA motif inhibiting Toll-like receptors 7 and 8.

RNA (New York, N.Y.) - 1 Sept 2017

Schmitt Felix C F, Freund Isabel, Weigand Markus A, Helm Mark, Dalpke Alexander H, Eigenbrod Tatjana

Abstract excerpt

Bacterial RNA serves an important function as activator of the innate immune system. In humans bacterial RNA is sensed by the endosomal receptors TLR7 and TLR8. Differences in the posttranscriptional modification profile of prokaryotic when compared with eukaryotic RNA allow innate immune cells to discriminate between "host" and "foreign" RNA. Ribose 2'-O-methylation is of particular importance and has been...

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Source

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Identifiers

PMID: 28576825
DOI: 10.1261/rna.061952.117
PMCID: PMC5558904

Genes

TLR7
TLR8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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