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Detection of Microbial Infections Through Innate Immune Sensing of Nucleic Acids

8 Sept 2018

Abstract excerpt

Microbial infections are recognized by the innate immune system through germline-encoded pattern recognition receptors (PRRs). As most microbial pathogens contain DNA and/or RNA during their life cycle, nucleic acid sensing has evolved as an essential strategy for host innate immune defense. Pathogen-derived nucleic acids with distinct features are recognized by specific host PRRs localized in endolysosomes and...

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PMID: 30200854
DOI: 10.1146/annurev-micro-102215-095605

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