Back to search

Article

SQLE facilitates laryngeal squamous cell carcinoma progression via PI3K/AKT signaling-mediated dysregulation of lipid metabolism

2025-06-24

Abstract excerpt

<title>Abstract</title> <p><bold>Background: </bold>Squalene Monooxygenase (SQLE) is the second rate-limiting enzyme in cholesterol biosynthesis and plays a critical role in the cholesterol biosynthesis pathway. SQLE has recently been shown to play animportant role in human tumors. However,its role in laryngeal squamous cell carcinoma (LSCC) remains unclear. <bold>Methods: </bold>Single-cell sequencing (scRNA-seq...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
2fb90fb8-fa37-52cb-9818-2260958e3b76
DOI
10.21203/rs.3.rs-6825489/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
SQLE facilitates laryngeal squamous cell carcinoma progression via PI3K/AKT signaling-mediated dysregulation of lipid metabolismDOI 10.21203/rs.3.rs-6825489/v1
SQLE Knockdown inhibits bladder cancer progression by regulating the PTEN/AKT/GSK3β signaling pathway through P53Semantic proximity
SQLE, A Key Enzyme in Cholesterol Metabolism, Correlates With Tumor Immune Infiltration and Immunotherapy Outcome of Pancreatic AdenocarcinomaSemantic proximity
Squalene epoxidase promotes hepatocellular carcinoma development by activating STRAP transcription and TGF-β/SMAD signalingSemantic proximity
Squalene epoxidase promotes hepatocellular carcinoma development by activating STRAP transcription and TGF‐β/SMAD signallingSemantic proximity
SQLE-mediated squalene metabolism is critical for mitochondrial biogenesis and tumor development in K-ras-driven cancerSemantic proximity
A long non-coding RNA LINC00094 regulates the transcriptional expression of lipid metabolism-related genes as a new member of core regulatory circuitry in esophageal squamous cell carcinomaSemantic proximity
Increasing CYLD expression improved the prognosis by downregulating the mTOR/SREBP1/lipid metabolism pathway in HPV-negative OSCC patientsSemantic proximity
Expression and significance of squalene epoxidase in squamous lung cancerous tissues and pericarcinoma tissuesSemantic proximity
SQLE promotes osteosarcoma progression via activating TGFβ/SMAD signaling pathwaySemantic proximity
Profile of sphingolipid-related genes and its association with prognosis highlights sphingolipid metabolism in oral cancerSemantic proximity
ALOX15 may function as a tumor biomarker, transitioning from pan-cancer comprehensive analysis to validation within head and heck squamous cell carcinomaSemantic proximity
Lipid droplets’ functional protein caveolin-2 is associated with lipid metabolism-related molecule FABP5 and EMT marker E-cadherin in oral epithelial dysplasiaSemantic proximity
Select a neighboring publication to make it the new centre.