Article

Discovery of high affinity and specificity stapled peptide Bcl-xL inhibitors using bacterial surface display

2023-12-05

Abstract excerpt

Intracellular protein-protein interactions are involved in many different diseases, making them prime targets for therapeutic intervention. Several diseases are characterized by their overexpression of Bcl-x L , an anti-apoptotic B cell lymphoma 2 (Bcl-2) protein expressed on mitochondrial membranes. Bcl-x L overexpression inhibits apoptosis, and selective inhibition of Bcl-x L has the potential to increase can...

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Literature Corpus work: b2f47929-0394-5d0b-9e11-422eba5cdd2d
DOI: 10.1101/2023.12.05.570108

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