Article

Noise exposure-induced intestinal flora dysbiosis disrupts homeostasis of oxi-inflamm-barrier in the gut–brain axis of APP/PS1 mice: implications for early onset Alzheimer's disease

2020-04-06

Abstract excerpt

<title>Abstract</title> <p>Background: Environmental noise exposure and genetic risk factors are thought to be associated with gut microbiome that exacerbates Alzheimer’s disease (AD) pathology. However, the role and mechanism of environmental risk factors in early-onset AD (EOAD) pathogenesis remain unclear. <h4>Methods:</h4> We established APP/PS1 Tg and C57BL/6 (wild type [WT]) mouse models to evaluate the mol...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6ec21ad8-f365-5a9d-a236-061946aba79d
DOI: 10.21203/rs.3.rs-19045/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Noise exposure-induced intestinal flora dysbiosis disrupts homeostasis of oxi-inflamm-barrier in the gut–brain axis of APP/PS1 mice: implications for early onset Alzheimer's diseaseDOI 10.21203/rs.3.rs-19045/v1Read

Multi-omics data reveals aberrant gut microbiota-host glycerophospholipid metabolism in association with neuroinflammation in APP/PS1 miceSemantic proximity Read

Gut microbiota regulate cognitive deficits and amyloid deposition in a model of Alzheimer’s diseaseSemantic proximity Read

The genetic risk factors, molecular pathways, microRNAs, and the gut microbiome in Alzheimer's disease.Semantic proximity Read

Gut-derived β-amyloid: Likely a centerpiece of the gut–brain axis contributing to Alzheimer’s pathogenesisSemantic proximity Read

The Potential Role of Gut Microbiota in Alzheimer’s Disease: From Diagnosis to TreatmentSemantic proximity Read

Alzheimer’s Disease Histological and Behavioral Manifestations in Transgenic Mice Correlate with Specific Gut Microbiome StateSemantic proximity Read

The role of gut microbiota in pathogenesis of Alzheimer's diseaseSemantic proximity Read

Gut microbiota dysbiosis in Alzheimer's disease (AD): Insights from human clinical studies and the mouse AD modelsSemantic proximity Read

Alterations in the Gut-Microbial-Inflammasome-Brain Axis in a Mouse Model of Alzheimer’s DiseaseSemantic proximity Read

Ginkgo biloba Extract Drives Gut Flora and Microbial Metabolism Variation in a Mouse Model of Alzheimer’s DiseaseSemantic proximity Read

Transmission of Alzheimer’s disease-associated microbiota dysbiosis and its impact on cognitive function: evidence from mice and patientsSemantic proximity Read

The link between gut microbiome and Alzheimer's disease: From the perspective of new revised criteria for diagnosis and staging of Alzheimer's diseaseSemantic proximity Read