Article

Human Genetic Analysis Reveals Circulating Alpha-1 Antitrypsin Level as a Protective Factor in Sepsis

2026-03-27

Abstract excerpt

Sepsis is a dysregulated host response to infection and a leading cause of global mortality, yet effective targeted therapies remain lacking. Here, we applied a proteogenomic framework integrating large-scale human genetics with circulating proteomics to identify therapeutic targets. In a meta-analysis of genome-wide association studies of 60,314 sepsis cases and 1,464,733 controls, we identified four genome-wide...

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Literature Corpus work: b2ea5127-e76f-5e4d-ae18-b03b6147e992
DOI: 10.64898/2026.03.25.26349312

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