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Article

Interaction between coxsackievirus B3 infection and α-synuclein in models of Parkinson’s disease

25 Oct 2021

Abstract excerpt

Parkinson's disease (PD) is one of the most common neurodegenerative diseases. PD is pathologically characterized by the death of midbrain dopaminergic neurons and the accumulation of intracellular protein inclusions called Lewy bodies or Lewy neurites. The major component of Lewy bodies is α-synuclein (α-syn). Prion-like propagation of α-syn has emerged as a novel mechanism in the progression of PD. This...

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PMID: 34695168
DOI: 10.1371/journal.ppat.1010018

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