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Integrated bulk and single-cell transcriptomic analysis reveals a tryptophan metabolism-driven prognostic signature and therapeutic landscape in triple- negative breast cancer

2026-04-03

Abstract excerpt

<title>Abstract</title> <p> <bold>Background:</bold> Triple-negative breast cancer (TNBC) is an aggressive malignancy with limited therapeutic options and poor prognosis. The kynurenine pathway of tryptophan metabolism contributes to an immunosuppressive tumor microenvironment (TME); however, its prognostic significance and molecular mechanisms in TNBC require further multi-omics characterization. <bold>Method...

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Literature Corpus work
3885d8ff-1d38-51cb-8c6f-894b05c2101e
DOI
10.21203/rs.3.rs-9287896/v1
Open publication

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Integrated bulk and single-cell transcriptomic analysis reveals a tryptophan metabolism-driven prognostic signature and therapeutic landscape in triple- negative breast cancerDOI 10.21203/rs.3.rs-9287896/v1
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