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N-glycosylation profiles of the SARS-CoV-2 spike D614G mutant and its ancestral protein characterized by advanced mass spectrometry.

Scientific reports - 7 Dec 2021

Wang Dongxia, Zhou Bin, Keppel Theodore R, Solano Maria, Baudys Jakub, Goldstein Jason, Finn M G, Fan Xiaoyu, Chapman Asheley P, Bundy Jonathan L, Woolfitt Adrian R, Osman Sarah H, Pirkle James L, Wentworth David E, Barr John R

Abstract excerpt

N-glycosylation plays an important role in the structure and function of membrane and secreted proteins. The spike protein on the surface of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes COVID-19, is heavily glycosylated and the major target for developing vaccines, therapeutic drugs and diagnostic tests. The first major SARS-CoV-2 variant carries a D614G substitution in...

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Angiotensin-Converting Enzyme 2
Chromatography, High Pressure Liquid
COVID-19
Glycopeptides

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mass Spectrometry

Spike Glycoprotein, Coronavirus

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Identifiers

PMID: 34876606
DOI: 10.1038/s41598-021-02904-w
PMCID: PMC8651636

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