Article

Modelling oxaliplatin resistance in colorectal cancer reveals a <i>SERPINE1</i> -based gene signature (RESIST-M) and therapeutic strategies for pro-metastatic CMS4 subtype

2024-12-18

Abstract excerpt

Drug resistance and distant metastases are major contributors to mortality in colorectal cancer (CRC). Here we investigate mechanisms underlying acquired resistance to oxaliplatin, a first-line, standard-of-care CRC treatment. We generated oxaliplatin-resistant CRC tumor cells with clinically relevant dosing regimen, which displayed enhanced metastatic potential. Transcriptomic and phenotypic analyses revealed a c...

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Literature Corpus work: b2c50dd6-e755-510d-9cd4-2aff9d24f63f
DOI: 10.1101/2024.12.17.628817

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