Article

Inhibition of JAK-STAT pathway corrects salivary gland inflammation and interferon driven immune activation in Sjögren’s Disease

2023-08-21

Abstract excerpt

<h4>Objectives</h4> Inflammatory cytokines that signal through the JAK-STAT pathway, especially interferons (IFNs), are implicated in Sjögren’s Disease (SjD). Although inhibition of JAKs is effective in other autoimmune diseases, a systematic investigation of IFN-JAK-STAT signaling and effect of JAK inhibitor (JAKi) therapy in SjD-affected human tissues has not been reported. <h4>Methods</h4> Human minor salivary...

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Literature Corpus work: b2c45194-fec2-55c2-8097-aace168c9b26
DOI: 10.1101/2023.08.16.23294130

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