Article
Molecular Subsetting of Interferon Pathways in Sjögren's Syndrome.
Arthritis & rheumatology (Hoboken, N.J.) - 1 Sept 2015
Hall John C, Baer Alan N, Shah Ami A, Criswell Lindsey A, Shiboski Caroline H, Rosen Antony, Casciola-Rosen Livia
Abstract excerpt
OBJECTIVE: Sjögren's syndrome (SS) is an autoimmune disease that targets the salivary and lacrimal glands. While all patients demonstrate inflammatory infiltration and abnormal secretory function in the target tissues, the disease features, pathology, and clinical course can vary. Activation of distinct inflammatory pathways may drive disease heterogeneity. The purpose of this study was to investigate whether...
Topics
- Adult
- Aged
- Antibodies, Antinuclear
- Case-Control Studies
- Female
- Humans
- Immunoblotting
- Interferon Type I
- Interferon-gamma
- Leukopenia
- Male
- Middle Aged
- Phenotype
- Salivary Glands, Minor
- Sjogren's Syndrome