Article

Mitochondrial double-stranded RNAs as a pivotal mediator in the pathogenesis of Sjögren’s syndrome

2021-09-13

Abstract excerpt

<h4>Objective</h4> Sjögren’s syndrome (SS) is a systemic autoimmune disease that targets the exocrine glands, resulting in impaired saliva and tear secretion. To date, type I interferons (I-IFNs) are increasingly recognized as pivotal mediators in SS, but their endogenous drivers have not been elucidated. This study investigates the role of mitochondrial double-stranded RNAs (mt-dsRNAs) in regulating I-IFN respon...

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Literature Corpus work: d22e3b28-e741-5f4c-97e2-bea8f0ab2e0d
DOI: 10.1101/2021.09.13.459934

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