Article

Amyloid aggregates accumulate in melanoma metastasis driving YAP mediated tumor progression

2020-02-11

Abstract excerpt

Melanoma progression is generally associated to increased Yes-associated protein (YAP) mediated transcription. Actually, mechanical signals from the extracellular matrix are sensed by YAP, which activates proliferative genes expression, promoting melanoma progression and drug resistance. Which and how extracellular signals induce mechanotransduction is not completely understood. Herein, by secretome studies, we re...

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Literature Corpus work: b2bece10-ea11-5c48-aa24-d8dfc6147fdf
DOI: 10.1101/2020.02.10.941906

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