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Article

A Feed-Forward Mechanosignaling Loop Confers Resistance to Therapies Targeting the MAPK Pathway in BRAF-Mutant Melanoma.

Cancer research - 15 May 2020

Girard Christophe A, Lecacheur Margaux, Ben Jouira Rania, Berestjuk Ilona, Diazzi Serena, Prod'homme Virginie, Mallavialle Aude, Larbret Frédéric, Gesson Maéva, Schaub Sébastien, Pisano Sabrina, Audebert Stéphane, Mari Bernard, Gaggioli Cédric, Leucci Eleonora, Marine Jean-Christophe, Deckert Marcel, Tartare-Deckert Sophie

Abstract excerpt

Aberrant extracellular matrix (ECM) deposition and stiffening is a physical hallmark of several solid cancers and is associated with therapy failure. BRAF-mutant melanomas treated with BRAF and MEK inhibitors almost invariably develop resistance that is frequently associated with transcriptional reprogramming and a de-differentiated cell state. Melanoma cells secrete their own ECM proteins, an event that is...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32179513
DOI: 10.1158/0008-5472.CAN-19-2914

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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