Article
Human Induced Pluripotent Stem Cell-Derived Engineered Heart Tissue as a Sensitive Test System for QT Prolongation and Arrhythmic Triggers.
Circulation. Arrhythmia and electrophysiology - 1 Jul 2018
Lemoine Marc D, Krause Tobias, Koivumäki Jussi T, Prondzynski Maksymilian, Schulze Mirja L, Girdauskas Evaldas, Willems Stephan, Hansen Arne, Eschenhagen Thomas, Christ Torsten
Abstract excerpt
BACKGROUND: Cardiac repolarization abnormalities in drug-induced and genetic long-QT syndrome may lead to afterdepolarizations and life-threatening ventricular arrhythmias. Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) should help to overcome the limitations of animal models based on species differences in repolarization reserve. Here, we compared head-to-head the contribution of IKs...
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