Article

Investigation into the mechanisms determining spontaneous activity in human-induced pluripotent stem cell-derived cardiomyocytes

2019-01-01

Abstract excerpt

Background: Human induced-pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) provide an alternative to adult primary cells for scientific and commercial research, but they have an embryonic rather than adult electrophysiological phenotype. In particular: low expression of inward rectifying channel (Ik1) contributes towards the unstable resting membrane potential and results in spontaneous electrical activity...

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Literature Corpus work: 1f7842f8-ef52-505b-8140-2477bfebe20b
DOI: 10.5525/gla.thesis.41143

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