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Article

Syncytium cell growth increases Kir2.1 contribution in human iPSC-cardiomyocytes

28 Sept 2020

Abstract excerpt

We identify cell culture density and cell-cell contact as an important factor in determining the expression of a key ion channel at the transcriptional and the protein levels, KCNJ2/Kir2.1, and its contribution to the electrophysiology of human induced pluripotent stem cell-derived cardiomyocytes. Our results indicate that studies on isolated cells, out of tissue context, may underestimate the cellular ion...

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Share to Cardiac electrophysiology and arrhythmias
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PMID: 32986966
DOI: 10.1152/ajpheart.00148.2020

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