Article

GAS-Luc2 Reporter Cell Lines for Immune Checkpoint Drug Screening in Solid Tumors

2023-09-27

Abstract excerpt

Recent studies highlight the integral role of the interferon gamma receptor pathway in T cell-mediated cytotoxicity against solid but not liquid tumors. IFNγ not only directly facilitates tumor cell death by T cells but also indirectly promotes cytotoxicity via myeloid phagocytosis. Meanwhile, full human ex vivo immune checkpoint drug screening remains challenging. We hypothesized engineered gamma interferon activ...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8c2bd555-8835-5ed4-ad5c-11948508f487
DOI: 10.21203/rs.3.rs-3290470/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

GAS-Luc2 Reporter Cell Lines for Immune Checkpoint Drug Screening in Solid TumorsDOI 10.21203/rs.3.rs-3290470/v1Read

Precision Immunotherapy: Revolutionizing Cancer Treatment With Targeted Innovations.Semantic proximity Read

Targeting Immune Checkpoints: Basic Signaling Pathways and Clinical Translation in Cancer TherapeuticsSemantic proximity Read

Autologous tumor-immune effusion co-cultures enable ex vivo functional profiling of radiotherapy-immunotherapy combinationsSemantic proximity Read

Advancement insights in cancer vaccines: mechanisms, types, and clinical applicationsSemantic proximity Read

Genetically engineered macrophages persist in solid tumors and locally deliver therapeutic proteins to activate immune responsesSemantic proximity Read

Immune checkpoint targeting in cancer therapy: toward combination strategies with curative potential.Semantic proximity Read

Human endogenous retrovirus-H long terminal repeat-associating 2: The next immune checkpoint for antitumour therapySemantic proximity Read

A Well-Controlled Experimental System to Study Interactions of Cytotoxic T Lymphocytes with Tumor CellsSemantic proximity Read

Single-cell transcriptomics reveals that tumor-infiltrating natural killer cells are activated by localized ablative immunotherapy and share anti-tumor signatures induced by immune checkpoint inhibitorsSemantic proximity Read

New horizons in cancer immunotherapy: The evolving role of R848 and R837 (Review)Semantic proximity Read

Genome-wide CRISPR screening identifies tyrosylprotein sulfotransferase-2 as a target for augmenting anti-PD1 efficacySemantic proximity Read

Type I Interferon Signaling via the EGR2 Transcriptional Regulator Potentiates CAR T Cell–Intrinsic DysfunctionSemantic proximity Read