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Circadian control of hepatitis B virus replication

12 Mar 2021

Abstract excerpt

Chronic hepatitis B virus (HBV) infection is a major cause of liver disease and cancer worldwide for which there are no curative therapies. The major challenge in curing infection is eradicating or silencing the covalent closed circular DNA (cccDNA) form of the viral genome. The circadian factors BMAL1/CLOCK and REV-ERB are master regulators of the liver transcriptome and yet their role in HBV replication is...

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PMID: 33712578
DOI: 10.1038/s41467-021-21821-0

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