Article
Mutations of the circadian clock genes Cry, Per, or Bmal1 have different effects on the transcribed and nontranscribed strands of cycling genes.
Proceedings of the National Academy of Sciences of the United States of America - 20 Feb 2024
Yang Yanyan, Wu Gang, Sancar Aziz, Hogenesch John B
Abstract excerpt
One important goal of circadian medicine is to apply time-of-day dosing to improve the efficacy of chemotherapy. However, limited knowledge of how the circadian clock regulates DNA repair presents a challenge to mechanism-based clinical application. We studied time-series genome-wide nucleotide excision repair in liver and kidney of wild type and three different clock mutant genotypes (Cry1-/-Cry2-/-,...
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