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Article

Exocyst Genes Are Essential for Recycling Membrane Proteins and Maintaining Slit Diaphragm in Drosophila Nephrocytes

1 Apr 2020

Abstract excerpt

Significance Statement Mutations in genes encoding the exocyst protein complex have been identified in patients with kidney disease, but the underlying mechanism of renal pathology is unclear. The authors demonstrated in Drosophila nephrocytes—counterparts to mammalian podocytes—that an intact exocyst complex is essential for normal function and structure. Silencing of various exocyst genes disrupted slit...

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Share to Cellular transport and secretion
Share to Genetic and Kidney Cyst Diseases
Share to Renal Diseases and Glomerulopathies

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PMID: 32238475
DOI: 10.1681/asn.2019060591

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