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Article

Association of -24CT, 1249GA, and 3972CT ABCC2 gene polymorphisms with methotrexate serum levels and toxic side effects in children with acute lymphoblastic leukemia.

Pediatric hematology and oncology - 1 Mar 2014

Sharifi Mohamad Jafar, Bahoush Gholamreza, Zaker Farhad, Ansari Shahla, Rafsanjani Khadijeh Arjmandi, Sharafi Heidar

Abstract excerpt

Acute lymphoblastic leukemia patients after being treated with methotrexate, have differences in methotrexate serum levels and toxic side effects. One of the main determinants of these toxic side effects is the host pharmacogenetics. The aim of this study was to evaluate the association of -24CT, 1249GA, and 3972CT ABCC2 gene polymorphisms with serum levels, and toxic side effects of methotrexate in childhood...

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Source

Identifiers

PMID: 24552501
DOI: 10.3109/08880018.2013.870625

Genes

ABCC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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