Article

A novel humanized PD-1/PD-L1 mouse model permits direct comparison of anti-tumor immunity generated by FDA-approved PD-1 and PD-L1 inhibitors

2022-06-13

Abstract excerpt

Seven different anti-PD-1 and PD-L1 monoclonal antibodies are now widely used in the US to treat a variety of cancer types, but there have been no clinical trials comparing them directly. Furthermore, because many of these antibodies do not cross react between mouse and human proteins, no preclinical models exist in which to consider these types of questions. Thus, we produced humanized PD-1 and PD-L1 mice in whic...

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Literature Corpus work: b23bdb33-d143-5d80-8f26-1eefb9342f7e
DOI: 10.21203/rs.3.rs-1659209/v1

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