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CD40 and CD80/86 signaling in cDC1s mediate effective neoantigen vaccination and generation of antigen-specific CX3CR1 <sup>+</sup> CD8 <sup>+</sup> T cells in mice

2020-06-15

Abstract excerpt

The use of tumor mutation-derived neoantigen represents a promising approach for cancer vaccines. Preclinical and early-phase human clinical studies have shown the successful induction of tumor neoepitope-directed responses; however, overall clinical efficacy of neoantigen vaccines has been limited. One major obstacle of this strategy is the prevailing lack of sufficient understanding of the mechanism underlying t...

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Literature Corpus work
e904c96e-9ebe-58c3-b48b-3ab29ea50458
DOI
10.1101/2020.06.15.151787
Open publication

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CD40 and CD80/86 signaling in cDC1s mediate effective neoantigen vaccination and generation of antigen-specific CX3CR1 <sup>+</sup> CD8 <sup>+</sup> T cells in miceDOI 10.1101/2020.06.15.151787
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