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Article

CD40 and CD80/86 signaling in cDC1s mediate effective neoantigen vaccination and generation of antigen-specific CX3CR1+ CD8+ T cells.

Cancer immunology, immunotherapy : CII - 1 Jan 2022

Yamauchi Takayoshi, Hoki Toshifumi, Oba Takaaki, Kajihara Ryutaro, Attwood Kristopher, Cao Xuefang, Ito Fumito

Abstract excerpt

The use of tumor mutation-derived neoantigen represents a promising approach for cancer vaccines. Preclinical and early phase human clinical studies have shown the successful induction of tumor neoepitope-directed responses; however, overall clinical efficacy of neoantigen vaccines has been limited. One major obstacle of this strategy is the prevailing lack of sufficient understanding of the mechanism underlying...

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Source

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Identifiers

PMID: 34037810
DOI: 10.1007/s00262-021-02969-6
PMCID: PMC8715856

Genes

CX3CR1
CD40
CD80
TLR3
CD70

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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