ErbB4 Activated p38γ MAPK Isoform Mediates Early Cardiogenesis Through NKx2.5 in Human Pluripotent Stem Cells

Abstract excerpt

Activation of ErbB4 receptor signaling is instrumental in heart development, lack of which results in embryonic lethality. However, mechanism governing its intracellular signaling remains elusive. Using human pluripotent stem cells, we show that ErbB4 is critical for cardiogenesis whereby its genetic knockdown results in loss of cardiomyocytes. Phospho-proteome profiling and Western blot studies attribute this...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cardiac Fibrosis and Remodeling
• Share to Congenital heart defects research
• Share to Signaling Pathways in Disease