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CRISPR/Cas9 genome editing to generate single variant <i>Plasmodium falciparum</i> lines and enable reverse genetic studies of PfEMP1 function in live parasites

2026-06-08

Abstract excerpt

Adhesion interactions between Plasmodium falciparum infected erythrocytes (IEs) and human cells bring about microvascular sequestration and contribute to severe malaria pathology. Parasite adhesion molecules on the IE surface are members of the P. falciparum erythrocyte membrane protein 1 (PfEMP1) family, encoded by var genes, which interact with receptors on human cells. Progress in understanding PfEMP1-host rece...

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Identifiers and source

Literature Corpus work
b21b3701-a304-5ca3-a1ab-77b3fc6a2b2d
DOI
10.64898/2026.06.07.729090
Open publication

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