<i>Plasmodium falciparum Plasmodium</i>helical interspersed subtelomeric proteins contribute to cytoadherence and anchor<i>P. falciparum</i>erythrocyte membrane protein 1 to the host cell cytoskeleton

Abstract excerpt

Adherence of Plasmodium falciparum-infected erythrocytes to host endothelium is conferred through the parasite-derived virulence factor P. falciparum erythrocyte membrane protein 1 (PfEMP1), the major contributor to malaria severity. PfEMP1 located at knob structures on the erythrocyte surface is anchored to the cytoskeleton, and the Plasmodium helical interspersed subtelomeric (PHIST) gene family plays a role in...

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