Article

A system for functional studies of the major virulence factor of malaria parasites

2024-04-30

Abstract excerpt

<h4>Summary</h4> PfEMP1 is a variable antigen displayed on erythrocytes infected with the malaria parasite Plasmodium falciparum . PfEMP1 mediates binding of the infected cell to the endothelium of blood vessels, a cause of severe malaria. Each parasite encodes ∼60 different PfEMP1 variants but only one is expressed at a time. Switching between variants underlies immune evasion in the host and variant-specific s...

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Literature Corpus work: b1d00067-6751-54cc-a713-9b6ecf2964cd
DOI: 10.1101/2024.04.30.591946

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